TUBE Seminar Series

TUBE Seminar Series introduction title, featuring the TUBE logo and EU funding sentence

TUBE organizes an active seminar programme for both consortium members and research students.  We feature speakers from all disciplines of TUBE research and encourage active participation from those present.

TUBE & ADAIR Seminar 

      Combined logos of TUBE, ADAIR and EU flag

 

Date: December 7, 2021

Time: 16.00 CET (can be subject to changes)

On-line event: Zoom

Topic: Cognition and brain MRI in seemingly healthy young adults exposed to PM2.5. – Role of developmental neurotoxicity. Where are we standing? (by Professor Lilian Calderón-Garciduenas, University of Montana and Universidad del Valle de México)

Lilian Calderón-Garcidueñas knew she wanted to be a physician by the time she finished middle school and she started medical school at age 15. Her pathology and neuropathology training at the University of Toronto were followed by her neuropathology fellowship at Harvard University, her Chief Pathology resident position at the University of Massachusetts at Worcester and her first position as an Assistant professor at Northwestern University in Chicago. She earned an American Board in Anatomical Pathology and Neuropathology in 1981. Her interest for clinical environmental research took her back to Chapel Hill, North Carolina where she earned a PhD in Toxicology in 2001, followed by three years as a postdoctoral fellow in Environmental Pathology. She is now affiliated as a professor at the Dept of Biomedical and Pharmaceutical Sciences at The University of Montana.

Her interest in air pollution and clinical environmental research took her back to school at the University of North Carolina at Chapel Hill, where she earned a degree in Toxicology in 2001, followed by a PostDoc in Environmental Pathology at the UNC Gillings School of Global Public Health.

Prof Calderón-Garcidueñas is interested in the chronic effects of exposure to air pollutants both indoors and outdoors in clinically healthy children. A crucial aspect is the role of cytokine imbalance in the respiratory tract, and cardiovascular pathology and on systemic effects.  In her most recent work, her team has described the development of quadruple aberrant protein pathology in the brains of children and young adult residents in Metropolitan Mexico City. The quadruple pathology includes Alzheimer hyperphosphorylated tau and beta amyloid, Parkinson alpha-synuclein, while the TAR DNA-binding protein 43 is seen in motor and non-motor neuronal groups. Interestingly, 99.5% of the 204 forensic autopsies in MMC residents ≤40y old had the AD hallmarks, 23% PD and 18% TDP-43 pathology in subjects with no extra-neural pathology. She emphasizes there is a common denominator, and the question to pursue is: are solid nanoparticles at the core of the problem? The problem is a serious one, >55% of the MMC young adults are cognitively impaired and in a recent work she showed an association between PTSD and pRBD, strengthening the possibility of a connection with misfolded proteinopathies in young urbanites.

More information: https://health.umt.edu/biomed/people/default.php?ID=1331

The TUBE-project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 814978.

The ADAIR project is funded under the 2019 JPCO-Fund call for Personalised Medicine under the grant number, JPND2019-466-037

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TUBE Seminar / 4

Date: November 4, 2021

Time: 15.00 CET (can be subject to changes)

On-line event: Zoom

– ‘Disease specific alterations in the olfactory mucosa of patients with Alzheimer’s disease’ (Riikka Lampinen, PhD student, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland)

–  ‘Changes in DNA methylation profile in AD olfactory mucosa’ (Katerina Honkova, PhD student, Institute of Experimental Medicine, Prague, The Czech Republic)

– ‘Air pollutants impair hiPSC-microglial function’ (Henna Konttinen, PhD student, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland

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TUBE Seminar / 3

Date: September 9, 2021

Time: 17.00 CET

On-line event: Zoom

‘TRAPs and neurodevelopmental disorders (autism)’ (Prof. Anthony Wexler, Assoc. Prof. Jill Silverman and Liz Berg, PhD,  from UCL Davis)

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TUBE Seminar / 2

Date: June 3, 2021

Time: 14.00 – 15.00 CET

On-line event: Zoom

‘Lung-deposited surface area ratio on size distribution of particulate matter’ (Jorge Vidal, MSc, Centro Mario Molina, Chile)

‘Characteristics and size of lung-deposited particles varies between high and low pollution traffic environments’ (Laura Salo, MSc, University of Tampere, Finland)

‘Chemical characterization of ambient particles in locations with contrasting emission sources’ (Luis Barreira, PhD, Finnish Meteorological Institute)

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TUBE Seminar / 1

Date: May 7, 2021

Time: 17.00 – 18.00 CET

On-line event: Zoom

‘Chronic exposure to ambient traffic-related air pollution promotes Alzheimer’s disease phenotypes in wildtype and genetically predisposed male and female rats’

Presented by:  Pamela J. Lein, PhD, Professor of Neurotoxicology, Chair, Department of Molecular Biosciences, Director, UC Davis Counter ACT Center of Excellence, UC Davis School of Veterinary Medicine, Australia

and Keith J. Bein, PhD, Associate Professional Researcher Air Quality Research Center, Research Professor Center for Health and the Environment at U.C. Davis, Australia